Atazanavir is not associated with an increased risk of cardio or cerebrovascular disease events
Identifieur interne : 005083 ( Main/Exploration ); précédent : 005082; suivant : 005084Atazanavir is not associated with an increased risk of cardio or cerebrovascular disease events
Auteurs : Antonella D'Arminio Monforte [Italie] ; Peter Reiss [Pays-Bas] ; Lene Ryom [Danemark] ; Wafaa Ei-Sadr [États-Unis] ; Francois Dabis [France] ; Stephane De Wit [Belgique] ; Signe W. Worm [Danemark] ; Mathew G. Law [Australie] ; Rainer Weber [Suisse] ; Ole Kirk [Danemark] ; Christian Pradier [France] ; Andrew N. Phillips [Royaume-Uni] ; Jens D. Lundgren [Danemark] ; Caroline A. Sabin [Royaume-Uni]Source :
- AIDS : (London) [ 0269-9370 ] ; 2013.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Objective: To investigate whether there is any association between exposure to atazanavir (ATV), either when boosted or unboosted by ritonavir, and myocardial infarction (MI) or stroke within the D:A:D: Study. Design: Prospective cohort collaboration. Methods: Poisson regression was used to investigate the association between cumulative exposure to ATV and MI/stroke risk after adjusting for known demographic and clinical confounders, as well as cumulative and recent exposure to specific antiretroviral drugs. Follow-up started on enrolment in the study and ended at the earliest of: a new MI/stroke event, death, 6 months after last clinic visit, or 1 February 2011. Results: The incidence of MI varied from 0.28 [95% confidence interval (CI) 0.26- 0.30)]/100 person-years of follow-up (PYFU) in those with no exposure to ATV to 0.20 (0.12-0.32)/100 PYFU in those with more than 3 years exposure. There was no evidence of an association between cumulative exposure to ATV and MI risk, either in univariate [relative rate/year 0.96 (95% CI 0.88-1.04)] or multivariable [0.95 (0.87-1.05)] analyses. The incidence of stroke was 0.17 (0.16-0.19)/100 PYFU in those with no exposure to ATV and 0.17 (0.10-0.27)/100 PYFU in those with more than 3 years exposure. As with the MI endpoint, there was no evidence of an association with ATV exposure in either univariate [1.02 (0.98-1.05)] or multivariable [0.95 (0.87-1.05)] analyses. Conclusion: These results argue against a class-wide association between exposure to HIV protease inhibitors and the risk of cardio/cerebrovascular events.
Affiliations:
- Australie, Belgique, Danemark, France, Italie, Pays-Bas, Royaume-Uni, Suisse, États-Unis
- Angleterre, Aquitaine, Canton de Zurich, Grand Londres, Hollande-Septentrionale, Hovedstaden, Nouvelle-Aquitaine, Nouvelle-Galles du Sud, Provence-Alpes-Côte d'Azur, Région de Bruxelles-Capitale, État de New York
- Amsterdam, Bordeaux, Bruxelles, Copenhague, Londres, Nice, Sydney, Zurich
- Université Bordeaux II, Université de Zurich
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Atazanavir is not associated with an increased risk of cardio or cerebrovascular disease events</title><author><name sortKey="D Arminio Monforte, Antonella" sort="D Arminio Monforte, Antonella" uniqKey="D Arminio Monforte A" first="Antonella" last="D'Arminio Monforte">Antonella D'Arminio Monforte</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Hospital San Paolo, University of Milan</s1><s3>ITA</s3><sZ>1 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Hospital San Paolo, University of Milan</wicri:noRegion></affiliation></author><author><name sortKey="Reiss, Peter" sort="Reiss, Peter" uniqKey="Reiss P" first="Peter" last="Reiss">Peter Reiss</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Academic Medical Center</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Ryom, Lene" sort="Ryom, Lene" uniqKey="Ryom L" first="Lene" last="Ryom">Lene Ryom</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Copenhagen HIV Programme, University of Copenhagen</s1><s2>Copenhagen</s2><s3>DNK</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Danemark</country><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Ei Sadr, Wafaa" sort="Ei Sadr, Wafaa" uniqKey="Ei Sadr W" first="Wafaa" last="Ei-Sadr">Wafaa Ei-Sadr</name><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Columbia University/Harlem Hospital</s1><s2>New York</s2><s3>USA</s3><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Dabis, Francois" sort="Dabis, Francois" uniqKey="Dabis F" first="Francois" last="Dabis">Francois Dabis</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>INSERM, Centre INSERM U897 'Epidémiologie et Biostatistique</s1><s3>FRA</s3><sZ>5 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Centre INSERM U897 'Epidémiologie et Biostatistique</wicri:noRegion><wicri:noRegion>INSERM, Centre INSERM U897 'Epidémiologie et Biostatistique</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Université Bordeaux Segalen, Institut de Santé Publique Epidémiologie Développement (ISPED)</s1><s2>Bordeaux</s2><s3>FRA</s3><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement><settlement type="city">Bordeaux</settlement></placeName><orgName type="university">Université Bordeaux II</orgName></affiliation></author><author><name sortKey="De Wit, Stephane" sort="De Wit, Stephane" uniqKey="De Wit S" first="Stephane" last="De Wit">Stephane De Wit</name><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>CHU Saint-Pierre Hospital, Department of Infectious Diseases</s1><s2>Brussels</s2><s3>BEL</s3><sZ>6 aut.</sZ></inist:fA14><country>Belgique</country><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Worm, Signe W" sort="Worm, Signe W" uniqKey="Worm S" first="Signe W." last="Worm">Signe W. Worm</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Copenhagen HIV Programme, University of Copenhagen</s1><s2>Copenhagen</s2><s3>DNK</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Danemark</country><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Law, Mathew G" sort="Law, Mathew G" uniqKey="Law M" first="Mathew G." last="Law">Mathew G. Law</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Kirby Institute, University of New South Wales</s1><s2>Sydney</s2><s3>AUS</s3><sZ>8 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Weber, Rainer" sort="Weber, Rainer" uniqKey="Weber R" first="Rainer" last="Weber">Rainer Weber</name><affiliation wicri:level="4"><inist:fA14 i1="09"><s1>Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich</s1><s3>CHE</s3><sZ>9 aut.</sZ></inist:fA14><country>Suisse</country><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName><orgName type="university">Université de Zurich</orgName></affiliation></author><author><name sortKey="Kirk, Ole" sort="Kirk, Ole" uniqKey="Kirk O" first="Ole" last="Kirk">Ole Kirk</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Copenhagen HIV Programme, University of Copenhagen</s1><s2>Copenhagen</s2><s3>DNK</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Danemark</country><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Pradier, Christian" sort="Pradier, Christian" uniqKey="Pradier C" first="Christian" last="Pradier">Christian Pradier</name><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>CHU Nice Hopital de I'Archet</s1><s2>Nice</s2><s3>FRA</s3><sZ>11 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Nice</settlement></placeName></affiliation></author><author><name sortKey="Phillips, Andrew N" sort="Phillips, Andrew N" uniqKey="Phillips A" first="Andrew N." last="Phillips">Andrew N. Phillips</name><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Research Department of Infection and Population Health, UCL</s1><s2>London</s2><s3>GBR</s3><sZ>12 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Lundgren, Jens D" sort="Lundgren, Jens D" uniqKey="Lundgren J" first="Jens D." last="Lundgren">Jens D. Lundgren</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Copenhagen HIV Programme, University of Copenhagen</s1><s2>Copenhagen</s2><s3>DNK</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Danemark</country><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Sabin, Caroline A" sort="Sabin, Caroline A" uniqKey="Sabin C" first="Caroline A." last="Sabin">Caroline A. Sabin</name><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Research Department of Infection and Population Health, UCL</s1><s2>London</s2><s3>GBR</s3><sZ>12 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">13-0099148</idno><date when="2013">2013</date><idno type="stanalyst">PASCAL 13-0099148 INIST</idno><idno type="RBID">Pascal:13-0099148</idno><idno type="wicri:Area/PascalFrancis/Corpus">000B93</idno><idno type="wicri:Area/PascalFrancis/Curation">005272</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000A94</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000A94</idno><idno type="wicri:doubleKey">0269-9370:2013:D Arminio Monforte A:atazanavir:is:not</idno><idno type="wicri:Area/Main/Merge">005268</idno><idno type="wicri:Area/Main/Curation">005083</idno><idno type="wicri:Area/Main/Exploration">005083</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Atazanavir is not associated with an increased risk of cardio or cerebrovascular disease events</title><author><name sortKey="D Arminio Monforte, Antonella" sort="D Arminio Monforte, Antonella" uniqKey="D Arminio Monforte A" first="Antonella" last="D'Arminio Monforte">Antonella D'Arminio Monforte</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Hospital San Paolo, University of Milan</s1><s3>ITA</s3><sZ>1 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Hospital San Paolo, University of Milan</wicri:noRegion></affiliation></author><author><name sortKey="Reiss, Peter" sort="Reiss, Peter" uniqKey="Reiss P" first="Peter" last="Reiss">Peter Reiss</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Academic Medical Center</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Ryom, Lene" sort="Ryom, Lene" uniqKey="Ryom L" first="Lene" last="Ryom">Lene Ryom</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Copenhagen HIV Programme, University of Copenhagen</s1><s2>Copenhagen</s2><s3>DNK</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Danemark</country><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Ei Sadr, Wafaa" sort="Ei Sadr, Wafaa" uniqKey="Ei Sadr W" first="Wafaa" last="Ei-Sadr">Wafaa Ei-Sadr</name><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Columbia University/Harlem Hospital</s1><s2>New York</s2><s3>USA</s3><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Dabis, Francois" sort="Dabis, Francois" uniqKey="Dabis F" first="Francois" last="Dabis">Francois Dabis</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>INSERM, Centre INSERM U897 'Epidémiologie et Biostatistique</s1><s3>FRA</s3><sZ>5 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Centre INSERM U897 'Epidémiologie et Biostatistique</wicri:noRegion><wicri:noRegion>INSERM, Centre INSERM U897 'Epidémiologie et Biostatistique</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Université Bordeaux Segalen, Institut de Santé Publique Epidémiologie Développement (ISPED)</s1><s2>Bordeaux</s2><s3>FRA</s3><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement><settlement type="city">Bordeaux</settlement></placeName><orgName type="university">Université Bordeaux II</orgName></affiliation></author><author><name sortKey="De Wit, Stephane" sort="De Wit, Stephane" uniqKey="De Wit S" first="Stephane" last="De Wit">Stephane De Wit</name><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>CHU Saint-Pierre Hospital, Department of Infectious Diseases</s1><s2>Brussels</s2><s3>BEL</s3><sZ>6 aut.</sZ></inist:fA14><country>Belgique</country><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Worm, Signe W" sort="Worm, Signe W" uniqKey="Worm S" first="Signe W." last="Worm">Signe W. Worm</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Copenhagen HIV Programme, University of Copenhagen</s1><s2>Copenhagen</s2><s3>DNK</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Danemark</country><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Law, Mathew G" sort="Law, Mathew G" uniqKey="Law M" first="Mathew G." last="Law">Mathew G. Law</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Kirby Institute, University of New South Wales</s1><s2>Sydney</s2><s3>AUS</s3><sZ>8 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Weber, Rainer" sort="Weber, Rainer" uniqKey="Weber R" first="Rainer" last="Weber">Rainer Weber</name><affiliation wicri:level="4"><inist:fA14 i1="09"><s1>Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich</s1><s3>CHE</s3><sZ>9 aut.</sZ></inist:fA14><country>Suisse</country><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName><orgName type="university">Université de Zurich</orgName></affiliation></author><author><name sortKey="Kirk, Ole" sort="Kirk, Ole" uniqKey="Kirk O" first="Ole" last="Kirk">Ole Kirk</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Copenhagen HIV Programme, University of Copenhagen</s1><s2>Copenhagen</s2><s3>DNK</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Danemark</country><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Pradier, Christian" sort="Pradier, Christian" uniqKey="Pradier C" first="Christian" last="Pradier">Christian Pradier</name><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>CHU Nice Hopital de I'Archet</s1><s2>Nice</s2><s3>FRA</s3><sZ>11 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Nice</settlement></placeName></affiliation></author><author><name sortKey="Phillips, Andrew N" sort="Phillips, Andrew N" uniqKey="Phillips A" first="Andrew N." last="Phillips">Andrew N. Phillips</name><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Research Department of Infection and Population Health, UCL</s1><s2>London</s2><s3>GBR</s3><sZ>12 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Lundgren, Jens D" sort="Lundgren, Jens D" uniqKey="Lundgren J" first="Jens D." last="Lundgren">Jens D. Lundgren</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Copenhagen HIV Programme, University of Copenhagen</s1><s2>Copenhagen</s2><s3>DNK</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Danemark</country><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Sabin, Caroline A" sort="Sabin, Caroline A" uniqKey="Sabin C" first="Caroline A." last="Sabin">Caroline A. Sabin</name><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Research Department of Infection and Population Health, UCL</s1><s2>London</s2><s3>GBR</s3><sZ>12 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><series><title level="j" type="main">AIDS : (London)</title><title level="j" type="abbreviated">AIDS : (Lond.)</title><idno type="ISSN">0269-9370</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">AIDS : (London)</title><title level="j" type="abbreviated">AIDS : (Lond.)</title><idno type="ISSN">0269-9370</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>AIDS</term><term>Antiretroviral agent</term><term>Antiviral</term><term>Atazanavir</term><term>Cardiovascular disease</term><term>Cerebrovascular disease</term><term>Human immunodeficiency virus</term><term>Myocardial infarction</term><term>Risk factor</term><term>Stroke</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Pathologie cérébrovasculaire</term><term>Pathologie de l'appareil circulatoire</term><term>SIDA</term><term>Atazanavir</term><term>Facteur risque</term><term>Infarctus du myocarde</term><term>Accident cérébrovasculaire</term><term>Virus immunodéficience humaine</term><term>Antiviral</term><term>Antirétroviral</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective: To investigate whether there is any association between exposure to atazanavir (ATV), either when boosted or unboosted by ritonavir, and myocardial infarction (MI) or stroke within the D:A:D: Study. Design: Prospective cohort collaboration. Methods: Poisson regression was used to investigate the association between cumulative exposure to ATV and MI/stroke risk after adjusting for known demographic and clinical confounders, as well as cumulative and recent exposure to specific antiretroviral drugs. Follow-up started on enrolment in the study and ended at the earliest of: a new MI/stroke event, death, 6 months after last clinic visit, or 1 February 2011. Results: The incidence of MI varied from 0.28 [95% confidence interval (CI) 0.26- 0.30)]/100 person-years of follow-up (PYFU) in those with no exposure to ATV to 0.20 (0.12-0.32)/100 PYFU in those with more than 3 years exposure. There was no evidence of an association between cumulative exposure to ATV and MI risk, either in univariate [relative rate/year 0.96 (95% CI 0.88-1.04)] or multivariable [0.95 (0.87-1.05)] analyses. The incidence of stroke was 0.17 (0.16-0.19)/100 PYFU in those with no exposure to ATV and 0.17 (0.10-0.27)/100 PYFU in those with more than 3 years exposure. As with the MI endpoint, there was no evidence of an association with ATV exposure in either univariate [1.02 (0.98-1.05)] or multivariable [0.95 (0.87-1.05)] analyses. Conclusion: These results argue against a class-wide association between exposure to HIV protease inhibitors and the risk of cardio/cerebrovascular events.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Belgique</li><li>Danemark</li><li>France</li><li>Italie</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Suisse</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Aquitaine</li><li>Canton de Zurich</li><li>Grand Londres</li><li>Hollande-Septentrionale</li><li>Hovedstaden</li><li>Nouvelle-Aquitaine</li><li>Nouvelle-Galles du Sud</li><li>Provence-Alpes-Côte d'Azur</li><li>Région de Bruxelles-Capitale</li><li>État de New York</li></region><settlement><li>Amsterdam</li><li>Bordeaux</li><li>Bruxelles</li><li>Copenhague</li><li>Londres</li><li>Nice</li><li>Sydney</li><li>Zurich</li></settlement><orgName><li>Université Bordeaux II</li><li>Université de Zurich</li></orgName></list><tree><country name="Italie"><noRegion><name sortKey="D Arminio Monforte, Antonella" sort="D Arminio Monforte, Antonella" uniqKey="D Arminio Monforte A" first="Antonella" last="D'Arminio Monforte">Antonella D'Arminio Monforte</name></noRegion></country><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Reiss, Peter" sort="Reiss, Peter" uniqKey="Reiss P" first="Peter" last="Reiss">Peter Reiss</name></region></country><country name="Danemark"><region name="Hovedstaden"><name sortKey="Ryom, Lene" sort="Ryom, Lene" uniqKey="Ryom L" first="Lene" last="Ryom">Lene Ryom</name></region><name sortKey="Kirk, Ole" sort="Kirk, Ole" uniqKey="Kirk O" first="Ole" last="Kirk">Ole Kirk</name><name sortKey="Lundgren, Jens D" sort="Lundgren, Jens D" uniqKey="Lundgren J" first="Jens D." last="Lundgren">Jens D. Lundgren</name><name sortKey="Worm, Signe W" sort="Worm, Signe W" uniqKey="Worm S" first="Signe W." last="Worm">Signe W. Worm</name></country><country name="États-Unis"><region name="État de New York"><name sortKey="Ei Sadr, Wafaa" sort="Ei Sadr, Wafaa" uniqKey="Ei Sadr W" first="Wafaa" last="Ei-Sadr">Wafaa Ei-Sadr</name></region></country><country name="France"><noRegion><name sortKey="Dabis, Francois" sort="Dabis, Francois" uniqKey="Dabis F" first="Francois" last="Dabis">Francois Dabis</name></noRegion><name sortKey="Dabis, Francois" sort="Dabis, Francois" uniqKey="Dabis F" first="Francois" last="Dabis">Francois Dabis</name><name sortKey="Pradier, Christian" sort="Pradier, Christian" uniqKey="Pradier C" first="Christian" last="Pradier">Christian Pradier</name></country><country name="Belgique"><region name="Région de Bruxelles-Capitale"><name sortKey="De Wit, Stephane" sort="De Wit, Stephane" uniqKey="De Wit S" first="Stephane" last="De Wit">Stephane De Wit</name></region></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Law, Mathew G" sort="Law, Mathew G" uniqKey="Law M" first="Mathew G." last="Law">Mathew G. Law</name></region></country><country name="Suisse"><region name="Canton de Zurich"><name sortKey="Weber, Rainer" sort="Weber, Rainer" uniqKey="Weber R" first="Rainer" last="Weber">Rainer Weber</name></region></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Phillips, Andrew N" sort="Phillips, Andrew N" uniqKey="Phillips A" first="Andrew N." last="Phillips">Andrew N. Phillips</name></region><name sortKey="Sabin, Caroline A" sort="Sabin, Caroline A" uniqKey="Sabin C" first="Caroline A." last="Sabin">Caroline A. Sabin</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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